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Found 3 matching student topics

Displaying 1–3 of 3 results

Traces of zinc and ciprofloxacin loaded polymer nanoparticulate inhaled formulations against lung infections associated with COPD and CF (CLIN08)

Lower respiratory tract infections (LRTIs) are one of the fatal diseases of the lungs that have severe impacts on public health, especially for Indigenous people. The currently available antibiotics administered orally for the treatment of LRTIs need high doses with frequent administration and cause dose-related adverse effects. To overcome this problem, we will investigate the development of ciprofloxacin (CIP) loaded poly(2-ethyl-2-oxazoline) (PEtOx) nanoparticles (NPs) with traces of zinc for potential pulmonary delivery from dry powder inhaler (DPI) formulations. As zinc …

Study level
PhD
Faculty
Faculty of Health
School
School of Clinical Sciences
Research centre(s)

Centre for Immunology and Infection Control

Improving platinum-based chemotherapy by targeting drug metabolism in lung cancer

Lung cancer is the deadliest cancer accounting for 18.4% of all cancer-related deaths. Platinum-based chemotherapy remains a key treatment option for most people living with this disease, either as adjuvant therapy or in combination with immunotherapy. However, resistance to therapy is a significant issue in the treatment of lung cancer. Novel therapeutic strategies combined with predictive biomarkers chemotherapy response are needed to transform the clinical management of NSCLC.Our published work has identified novel biomarkers and druggable proteins from deregulated protein …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)
Centre for Genomics and Personalised Health

A novel diagnostic test for lung transplant rejection – circulating cell-free methylated DNA

Lung transplantation is a complex medical procedure for those with advanced lung disease. Average survival following lung transplantation is shorter than for any other solid organ. The median survival time of a lung transplant recipient is only 8 years due to a high incidence (over 75% at 10 years) of chronic rejection (also called chronic lung allograft dysfunction – CLAD). The clinical course of CLAD is progressive with irreversible lung injury that ultimately leads to lung failure. The median survival …

Study level
PhD
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)
Centre for Genomics and Personalised Health

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